#Protease inhibitor

[sophsweet]

How Philanthropists hijacked COVID-19

Since early 2020, some observant people have speculated about where all the money committed by the Gates Foundation in January 2020 was going. The Bill and Melinda Gates website proudly announce their work to fight covid-19 from January 2020. How did they know how Coronavirus Disease 2019 would cause a global pandemic? Defensive institutes such as the main subject of this blog, patronisingly…

[drpedi07]

Atazanavir Drug

Medical information for Atazanavir on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Renal Dose, Hepatic Dose

[neil-gaiman]

Hi Neil,

I’ve just realised something.

In Good Omens, Pollution is a horseperson of the apocalypse instead of Pestilence.

The novel was published in 1990 at the height of the AIDS crisis.

At the time, did you think about how that creative choice would resonate in the context of that particular pestilence? Also, are there ways in which echoes of the AIDS crisis appear in Good Omens? 

[These are genuine, non-judgmental questions. I’m too young to have experienced the pre-protease inhibitor era of the AIDS crisis. But I know it was a time of unimaginable tragedy in creative professions, exacerbated by institutional neglect and suffering. So writing at that time must have been fraught in complex ways. Thanks for your insights]

You might have forgotten the whole quote:

Pollution removed his helmet and shook out his long white hair. He had taken over when Pestilence, muttering about penicillin, had retired in 1936. If only the old boy had known what opportunities the future had held…

You'll find a fair amount of writing about what it was like working and living through that time, and why I created the Death Talks About Life public service comic here in this blog on Tumblr.

[hegory-grousing]

House felt Wilson’s light laugh. It vibrated through Wilson’s chest and into House’s shoulder, ending in an exhale against his neck. House barely repressed a shiver. “I really thought you’d given up this freaky little fetish,” House said. “I’ve been into the hug-stuff my whole life. Not stopping now.” “And you won’t rest until you’ve dragged the rest of us down with you and your vile habit.” “Exactly. Now, what were you going to tell me about protease inhibitors?” - Experimental Procedures by ORiley42 on Ao3

silly image I made of a bit from one of my absolute favorite house fics, Experimental Procedures by @oriley42. go read it it's fucking phenomenal

[covid-safer-hotties]

Also preserved on our archive

By Mary Van Beusekom, MS

SARS-CoV-2, the virus that causes COVID-19, is more infectious than severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) viruses because it contains an enzyme that can efficiently circumvent a host cell's innate defense mechanism, Kobe University–led researchers in Japan suggest in the Journal of Virology.

The innate immune system attaches the molecular tag ISG15 to SARS-CoV-2's nucleocapsid protein, which contains the virus's genetic material, inhibiting viral replication. The team's laboratory experiments suggest that the virus's papain-like protease (PLpro) can remove the tag, recovering its ability to assemble new viruses and escape the innate immune response.

Discovery may lead to more effective drugs While the SARS and MERS viruses belong to the same virus family and also have an enzyme that can remove the ISG15 tag, their versions are less efficient and have a different primary target than that of SARS-CoV-2.

In a Kobe University news release today, senior author Ikuo Shoji, MD, PhD, said this finding may help guide the development of more effective and selective COVID-19 inhibitors that target SARS-CoV-2's nucleocapsid protein.

"We may be able to develop new antiviral drugs if we can inhibit the function of the viral enzyme that removes the ISG15 tag," he said. "Future therapeutic strategies may also include antiviral agents that directly target the nucleocapsid protein, or a combination of these two approaches."

Study Link: journals.asm.org/doi/10.1128/jvi.00855-24

Press Release: www.eurekalert.org/news-releases/1061645

[dyke-terra]

Yo, Mia Dearden fans. Found a one off panel appearance in Manhunter (2004).

IMAGE ID: A comic panel showing Mia as Speedy looking at a bottle of pills with Ollie looking on. A voice from a TV says: Many beneficial drugs already on the market-- such as some protease inhibitors used by HIV patients-- are ethically questionable due to Vesetech's involvement in their development." END ID.

[tomafome]

Diamanda Galás’ left hand tattoo WE ARE ALL HIV+ (Photo: Peter Macdiarmid, 1994/7/7)

In 1992, when I wrote “we are all HIV positive” on my hand with a tattoo artist from Brooklyn, I said several things: One was that you may not separate the uninfected from the infected as so many so-called liberal doctors wanted to do, by putting the infected on Plum island outside of New York City. You cannot separate the uninfected from the infected by denying them access to your country. You cannot separate the uninfected from the infected by putting the infected on a separate floor that has red danger contagion signs and giving them crap to eat and instructing Catholic nurses not to administer painkillers to the guilty and allowing Catholic priests to visit them and inform them of their future in Hell if they do not confess that their entire life has been a crime. You cannot separate the infected from the uninfected by saying I do not have AIDS, I have syphillis, but most assuredly nothing to do with HIV, and then allow them to die an early death because they would rather die of the disease than the stigma, as so many did, and do, including my best friend—in 1996—who would be living today if he had not been petrified of the stigma and intentionally saw a doctor whose research was based on the option and the opinion that HIV did not cause AIDS. A second opinion, or better yet, my friend’s own research with other researchers would have been smarter. He knew better, but he told me when we first met in 1989 that he would kill himself if he were diagnosed with HIV. No matter what I said to him he continued to visit the one practitioner who would condone this denial for six years until it was too late, and the following year protease inhibitors hit the market—the year after he died. No, you cannot separate the uninfected from the infected by saying “I do not suffer from this virus: I have been spared.” Because one day, in one city, in one moment, you will learn that you suffer from some virus, some pathogen, something poisonous that will not exit from your body; and you will realize that you do not mourn the dead, you mourn the suffering of the living while they are still alive. No one can escape death, and worse than that, no one can escape the life of anything and everything that smells your blood and lives because of it.

Diamanda Galás, excerpt from “STIGMA”, in UPDATING THE PLAGUE AND THE MASS: PRAYERS FOR THE INFIDEL (2009/10/9)

[kunosoura]

Phone wallet keys… the fucking protease inhibitors

[elliepassmore]

It Was Vulgar and It Was Beautiful review

5/5 stars Recommended if you like: history, activism, LGBTQ+ history This book is probably one of the best nonfiction books I've read. The writing was engaging and I really connected with the people Lowery introduces in the pages. It's the kind of book that I was so invested in and whose content was so accessible that I wanted to just read it in one go. The book starts with an opening to the AIDS epidemic. We get to know some of the main people involved who were impacted by the crisis and how they reacted to it. I liked that we got this introduction instead of just jumping straight in to Gran Fury's work because it really explains the emotions of the time and how people felt compelled to act as well as just how devastating the AIDS epidemic was. While the main focus of the book is on Gran Fury and ACT UP, Lowery also follows the lives of the people involved in Gran Fury, some of the minutiae and politics of both, and how each can be placed in the context of the time. I actually think this information adds to the book and the story Lowery is telling, especially since it's information that might not be known to people coming into this book. It also helps to explain and provide context for some of the reactions of Gran Fury and ACT UP members (as well as other activists and organizations) later on in the book. The bulk of the book is spent describing the act Gran Fury created, the process of creating it, and the public's reaction to it. It was interesting to read about both the relatively unplanned, reactionary art that characterized the beginning of the movement and the more planned art that came later on. I definitely think this section is helpful for understanding how art and activism can stand together and how sometimes the message can get convoluted. Something I particularly liked about the book was that Lowery makes sure to point out that ACT UP was overwhelmingly white, overwhelmingly male, overwhelmingly cis. Despite the fact that Gran Fury recognized, and at times explicitly drew attention to, the fact that AIDS also impacted women, trans people, and people of color, the makeup of the groups weren't reflective of that fact. It was good to see that those things were acknowledge by Gran Fury, even if there was a gap in member representation. I also found it interesting how a number of Gran Fury members struggled with the so-called 'end of the AIDS epidemic' and recognized that protease inhibitors weren't the end for many, many people. Lowery also does not shy away from the truth and brutality of the AIDS epidemic and the sheer tragedy that came about as a result of the government's inaction. The number of people impacted by the crisis is incomprehensible, and Lowery makes sure that we readers understand that. It's definitely a heavy topic but I think it's important that it's included in the book. I can't really express how well I think this book does covering the topics it does and how it manages to be both thorough and engaging. I'll definitely be keeping my eye out for more nonfiction by Lowery.

[weakfleshwillingsoul]

2 separate protein preps failed within 2 days of each other. Spent a day harvesting and purifying A04 and pumping an insane amount of protease inhibitor into it just to have it die pathetically on the gel anyways, babysat it like a sick infant while it was on the centrifuge just to test the concentration and find there was no intact protein left in the solution. Same thing for the 292616, watched in horror as it ate shit on the chromatograph, ran a hail mary gel with the purified fractions regardless, every band was a handful of kilodaltons less than they should have been. No way of telling whether that was the chewed-up protein or some sort of uncanny contaminating imposter that eluted in its place. nearly 20 hours in the lab over the last couple days, exhausted to the point of surrealism ... had to discard everything. Must make new cultures on monday. Fifth A04 attempt, third 292616

[er-cryptid]

Aminocaproic Acid

Names -- Amicar -- Epsilon Aminocaproic Acid

Class -- hemostatic agent -- fibrinolysis inhibitor

Use -- management of acute, life-threatening hemorrhage due to systemic hyperfibrinolysis or urinary fibrinolysis -- prevention of recurrent subarachnoid hemorrhage -- prevention of bleeding following oral surgery for hemophiliacs -- management of severe hemorrhage caused by thrombolytic agents

Action -- inhibits activation of plasminogen -- plasminogen is a serum protease activated to form clots

[drpedi07]

Amprenavir Drug

Medical information for Amprenavir on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Renal Dose, Hepatic Dose.

[chocolatedetectivehottub]

goals plastic surgery,

goals plastic surgery,

Gynecomastia is a medical condition characterized by the enlargement of breast tissue in males. While it is a common condition, it can be a source of distress for those affected, often causing embarrassment and self-esteem issues. In this article, we will explore the causes, symptoms, and treatment options for gynecomastia to better understand this condition.

What is Gynecomastia?

Gynecomastia is the abnormal growth of glandular tissue in a male's chest, leading to breast enlargement. It can affect one or both breasts and may occur during different stages of life, such as infancy, puberty, or adulthood. The condition is often associated with an imbalance in the levels of the hormones estrogen and testosterone. Estrogen, a female hormone, can sometimes be present in higher amounts in men, leading to the development of gynecomastia.

Causes of Gynecomastia

The causes of gynecomastia can vary, and sometimes no specific cause is identified. However, common factors contributing to gynecomastia include:

Hormonal Imbalance: During puberty, the body undergoes hormonal changes that can lead to a temporary imbalance between estrogen and testosterone. In some cases, this imbalance results in the development of gynecomastia.

Aging: As men age, testosterone levels naturally decline, and this decrease can lead to an increase in the relative levels of estrogen, which may trigger the development of gynecomastia.

Medications: Certain medications can contribute to gynecomastia. These include:

Anti-androgens (used to treat prostate issues)

Anabolic steroids

Certain anti-depressants and anti-anxiety medications

Drugs for HIV/AIDS treatment (such as protease inhibitors)

Health Conditions: Underlying health conditions such as liver disease, kidney failure, thyroid disorders, or obesity can increase the risk of gynecomastia. These conditions can lead to hormone imbalances or affect the way the body processes estrogen.

Substance Use: Alcohol, marijuana, and certain recreational drugs can interfere with hormone production and lead to gynecomastia.

Obesity: Excess fat in the body, especially in the chest area, can sometimes mimic the appearance of gynecomastia, even though it is technically a result of fatty tissue accumulation rather than glandular tissue growth.

Symptoms of Gynecomastia

The most noticeable symptom of gynecomastia is the enlargement of breast tissue. Other common symptoms include:

Swelling or tenderness in the breast area

A lump or firm tissue under the nipple

Asymmetry, where one breast may be larger than the other

Pain or sensitivity in the chest area

In some cases, gynecomastia may not cause any physical pain but can still lead to psychological distress due to the appearance of the chest.

Diagnosing Gynecomastia

If you suspect you have gynecomastia, it's essential to consult a healthcare professional. They will typically begin with a physical examination and review your medical history. Additional tests may be conducted to identify the underlying cause of the condition, such as:

Blood tests to check hormone levels

Imaging tests, such as mammograms or ultrasounds, to examine the breast tissue

A biopsy to rule out breast cancer in rare cases

Treatment Options for Gynecomastia

Treatment for gynecomastia depends on the underlying cause, severity of the condition, and the individual's preferences. Options include:

Observation: If gynecomastia is caused by puberty, it may resolve on its own as hormone levels stabilize. In these cases, doctors may recommend simply monitoring the condition over time.

Medications: If the condition is due to an imbalance in hormones, medications may be prescribed to help correct this imbalance. Drugs like selective estrogen receptor modulators (SERMs), such as tamoxifen, are sometimes used to reduce breast tissue enlargement.

Surgery: For more persistent or severe cases, surgery may be necessary. The most common procedure for gynecomastia is liposuction, which removes excess fatty tissue, or mastectomy, which removes excess glandular tissue. Both procedures are generally safe and effective, and many patients experience significant improvements in chest appearance and self-esteem following surgery.

Lifestyle Changes: In some cases, reducing alcohol or drug use, losing weight, or addressing underlying health issues can improve the condition. Maintaining a healthy lifestyle can help reduce the risk of gynecomastia recurrence.

Conclusion

While gynecomastia is often a benign condition, it can have a significant emotional and psychological impact. Understanding the causes, symptoms, and treatment options can help those affected seek appropriate care. Whether the condition resolves on its own or requires medical intervention, gynecomastia can often be managed effectively, allowing individuals to regain confidence and improve their quality of life. If you believe you may have gynecomastia, it’s important to consult a healthcare provider for an accurate diagnosis and tailored treatment plan.

4o mini

O

[taniyaaskd]

Blood Plasma Market Value: Growth, Share, Size, Scope, Trends, Industry Analsis and Forecast by 2031

"Blood Plasma Market Size And Forecast by 2031

Global blood plasma market size was valued at USD 31.61 million in 2023 and is projected to reach USD 70.77 billion by 2031, with a CAGR of 10.60% during the forecast period of 2024 to 2031.

The Blood Plasma Market is a dynamic and rapidly evolving industry, encompassing a wide range of applications and opportunities. With significant advancements in technology, shifting consumer preferences, and increasing demand for innovative solutions, the market has grown to become a vital sector in the global economy. This report provides a comprehensive analysis of the Blood Plasma Market, covering its size, share, scope, and the key factors influencing its development.

Get a Sample PDF of Report - https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-blood-plasma-market

Which are the top companies operating in the Blood Plasma Market?

The Top 10 Companies in Blood Plasma Market include well-established players. These companies are known for their market expertise, strong product portfolios, and significant market share. Their innovation, customer focus, and global operations have helped them maintain leadership positions in the market, offering high-quality solutions and services that meet the evolving needs of consumers.

**Segments**

- On the basis of type, the global blood plasma market can be segmented into immunoglobulin, albumin, coagulation factor concentrates, protease inhibitors, and other plasma fractionation products. Immunoglobulin segment is expected to dominate the market during the forecast period due to the increasing use of immunoglobulin in the treatment of various diseases such as immune deficiencies, inflammatory diseases, and neurological disorders.

- By application, the market is divided into neurology, immunology, hematology, critical care, pulmonology, hemato-oncology, and others. The immunology segment is expected to witness significant growth owing to the rising prevalence of autoimmune diseases and the increasing use of immunoglobulin for their treatment.

- Based on end-user, the market is categorized into hospitals, clinical research laboratories, and academic institutions. The hospital segment is anticipated to hold a substantial share of the market due to the high demand for blood plasma products in hospital settings for various medical procedures and treatments.

**Market Players**

- Some of the key players in the global blood plasma market are CSL Limited, Grifols, S.A., Octapharma, Kedrion S.p.A., Biotest AG, Shanghai RAAS, Green Cross Corporation, Takeda Pharmaceutical Company Limited, China Biologic Products Holdings, Inc., and LFB S.A. These players are focusing on strategic initiatives such as mergers and acquisitions, collaborations, and product launches to enhance their market presence and expand their product portfolio.

- The market is highly competitive with the presence of several established players as well as small and medium-sized companies. Factors such as technological advancements, increasing R&D activities, and the growing demand for blood plasma products are driving the market growth. However, stringent regulations regarding the collection and processing of blood plasma products may hinder the market growth to some extent.

For more detailed insights, visit https://www.databridgemarketresearch.com/reports/global-blood-plasma-marketThe global blood plasma market is witnessing significant growth driven by various factors such as the increasing prevalence of autoimmune diseases, advancements in technology, and the rising demand for blood plasma products in hospital settings. As the market continues to evolve, key segments such as immunoglobulin, albumin, coagulation factor concentrates, and protease inhibitors are playing crucial roles in shaping the market landscape. Among these segments, immunoglobulin is expected to dominate the market due to its wide range of applications in the treatment of immune deficiencies, inflammatory diseases, and neurological disorders.

In terms of applications, the immunology segment is poised for substantial growth attributed to the rising incidence of autoimmune diseases worldwide. This trend is further fueled by the expanding utilization of immunoglobulin for the treatment of various autoimmune conditions. Additionally, the neurology, hematology, and critical care segments are also contributing significantly to the market growth as blood plasma products find increasing applications in these medical specialties.

End-users such as hospitals, clinical research laboratories, and academic institutions are key players in the blood plasma market. Hospitals, in particular, are expected to hold a substantial market share due to the high demand for blood plasma products for a wide range of medical procedures and treatments. Clinical research laboratories and academic institutions are also key contributors to the market as they play essential roles in research and development activities related to blood plasma products.

The competitive landscape of the global blood plasma market is characterized by the presence of established players such as CSL Limited, Grifols, S.A., and Octapharma, along with several small and medium-sized companies. These market players are actively engaged in strategic initiatives such as mergers and acquisitions, collaborations, and product launches to strengthen their market presence and expand their product portfolios. While factors such as technological advancements and increasing R&D activities are driving market growth, stringent regulations regarding the collection and processing of blood plasma products pose challenges to market expansion.

In conclusion, the global blood plasma market is poised for robust growth driven by the increasing prevalence of autoimmune diseases, technological advancements, and the growing demand for blood plasma products in hospital settings. Key market segments such as immunoglobulin and applications such as immunology are expected to witness significant growth, while market players are focusing on strategic initiatives to enhance their market presence. Despite challenges posed by regulatory constraints, the market is expected to continue its upward trajectory in the coming years.**Segments**

Global Blood Plasma Market Segmentation: - Type: Hyperimmune Globulin, Albumin, Factor VIII, Factor IX, Immunoglobulin, Others - Mode of Delivery: Infusion Solutions, Gels, Sprays, Biomedical Sealants - Therapeutic Indication: Immunology, Oncology, Pulmonology, Rheumatology, Transplantation, Neurology, Hematology, Other - Application: Hypogammaglobulinemia, Immunodeficiency Diseases, Hemophilia, Von Willebrand's Disease (vWD), Others - End User: Hospitals, Clinics, Others

**Market Players**

- Allergan (Ireland) - AbbVie Inc. (US) - GALDERMA (Switzerland) - Evolus, Inc. (US) - Revance (US) - HUGEL, Inc. (South Korea) - Ipsen Pharma (France) - USWM, LLC. (US) - Sun Pharmaceutical Industries Ltd. (India) - Pfizer Inc. (US) - GlaxoSmithKline plc (UK) - Merz Pharma (Germany) - Medytox (South Korea) - Smith+Nephew (US) - Sanofi (France) - Novartis AG (Switzerland) - Teva Pharmaceutical Industries Ltd. (Israel) - LGM Pharma. (US) - Lannett (US) - NorthStar Rx LLC (US) - Par Pharmaceutical (US)

The global blood plasma market is experiencing substantial growth driven by factors such as the increasing prevalence of autoimmune diseases, technological advancements, and the rising demand for blood plasma products in hospital settings. Key segments like immunoglobulin, albumin, coagulation factor concentrates, and protease inhibitors play vital roles in shaping the market landscape, with immunoglobulin expected to dominate due to its versatile applications in treating various diseases. The immunology segment is projected to witness significant growth, fueled by the rising incidence of autoimmune diseases globally and the expanding use of immunoglobulin in their treatment. Hospitals are expected to maintain a significant market share, given the high demand for blood plasma products in medical procedures. The market competitiveness, driven by established players and emerging companies, is marked by strategic initiatives to enhance market presence and product portfolios. While technological advancements and increased R&D activities propel market growth, regulatory constraints in blood plasma product collection and processing pose challenges to market expansion. Despite these obstacles, the market is on a trajectory of continued growth, driven by evolving trends and increasing demand for advanced therapies in various medical specialties.

Explore Further Details about This Research Blood Plasma Market Report https://www.databridgemarketresearch.com/reports/global-blood-plasma-market

Key Insights from the Global Blood Plasma Market :

Comprehensive Market Overview: The Blood Plasma Market is experiencing robust growth, fueled by increasing adoption of innovative technologies and evolving consumer demands.

Industry Trends and Projections: The market is expected to grow at a CAGR of X% over the next five years, with digital transformation and sustainability driving key trends.

Emerging Opportunities: Rising consumer demand for eco-friendly and customizable products is creating significant market opportunities.

Focus on R&D: Companies are intensifying their focus on R&D to develop advanced solutions and stay ahead of emerging market trends.

Leading Player Profiles: Key players are at the forefront, with strong market shares and continuous innovation.

Market Composition: The market consists of a mix of large established players and smaller, agile companies, each contributing to dynamic competition.

Revenue Growth: The market is experiencing steady revenue growth, driven by increased consumer spending and expanding product offerings.

Commercial Opportunities: There are ample commercial opportunities in untapped regions, particularly in emerging economies with growing demand.

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[vineetlabs]

A Leading Manufacturer of Ritonavir Intermediates & API in India

Vineet Labs is a prominent player in the pharmaceutical industry, renowned for its expertise in manufacturing high-quality Active Pharmaceutical Ingredients (APIs) and intermediates. With a strong focus on innovation and quality, Vineet Labs has established itself as a leading supplier of Ritonavir intermediates and API in India.

Ritonavir: A Critical Antiretroviral Drug

Ritonavir is a crucial antiretroviral medication used in the treatment of HIV/AIDS. It belongs to a class of drugs known as protease inhibitors, which work by blocking the enzyme protease, essential for the replication of the HIV virus.

Vineet Labs' Role in Ritonavir Production

Vineet Labs plays a vital role in the production of Ritonavir by manufacturing key intermediates required for the synthesis of the final API. These intermediates are crucial building blocks in the complex chemical synthesis process of Ritonavir.

Key Strengths of Vineet Labs:

State-of-the-art Manufacturing Facilities: Vineet Labs boasts modern and well-equipped manufacturing facilities adhering to stringent quality standards like GMP (Good Manufacturing Practices). Focus on Quality and Compliance: The company prioritizes quality and compliance in all its operations, ensuring that all products meet the highest regulatory standards. Experienced Team: Vineet Labs has a team of highly skilled and experienced professionals with expertise in pharmaceutical chemistry and manufacturing. Strong R&D Capabilities: Continuous research and development efforts enable Vineet Labs to optimize manufacturing processes, improve product quality, and develop innovative solutions. Customer Focus: The company maintains strong customer relationships, providing excellent service and support to its clients globally. Contribution to Global Healthcare

By efficiently manufacturing Ritonavir intermediates and API, Vineet Labs contributes significantly to the global fight against HIV/AIDS. Access to affordable and high-quality antiretroviral medications is crucial for effective treatment and improved patient outcomes.

Conclusion

Vineet Labs is a key player in the Indian pharmaceutical industry, making significant contributions to the production of essential medicines like Ritonavir. With its commitment to quality, innovation, and customer satisfaction, Vineet Labs continues to play a vital role in improving global healthcare access.